Amoxycillin trihydrate price index

Amoxycillin trihydrate price December 2025 and outlook (see chart below)

• Northeast Asia:US$29.96/KG, 1.6% up
• India:US$25.97/KG, 4.8% up

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Amoxycillin trihydrate price index

This post is a summary of the Amoxycillin trihydrate price developments. The price developments of Amoxycillin trihydrate are expressed in US$ prices converted FX rates applicable at the time when the price was valid. Amoxycillin trihydrate price index developments are calculated from multiple separate sources of data to ensure statistical accuracy.

The outlook for Amoxycillin trihydrate prices is generated from different inputs including:

• Very recent price developments of immediate cost drivers of Amoxycillin trihydrate prices
• Recent price developments of underlying feedstocks which drive the price of Amoxycillin trihydrate
• Market futures for both cost drives and feedstocks of Amoxycillin trihydrate prices
• Adjustment of current supply/demand imbalances in the Amoxycillin trihydrate market
• Longer term trends in likely demand conditions

What is Amoxycillin trihydrate and what is it used for

Amoxycillin trihydrate is the crystalline trihydrate salt form of amoxicillin, a broad-spectrum, semi-synthetic aminopenicillin antibiotic. It acts by inhibiting bacterial cell-wall synthesis (binding penicillin-binding proteins) and is widely used to treat common bacterial infections such as otitis media, sinusitis, streptococcal pharyngitis, lower respiratory tract infections, urinary tract infections and skin/soft tissue infections; it is also formulated with clavulanate for β-lactamase–producing organisms.

How is Amoxycillin trihydrate produced

Commercial production typically begins from 6-aminopenicillanic acid (6-APA) and a suitably protected side-chain (for example D-(-)p-hydroxyphenylglycine derivatives) followed by chemical acylation to give amoxicillin, isolation and conversion to the trihydrate crystalline form. Processes include batch and increasingly continuous reactive-crystallization approaches to improve yield and impurity profiles; older and still-used routes (e.g., aqueous chloride/hydrochloride acylation and Dane-salt methods) and specific crystallization/reslurrying steps to obtain the trihydrate are described in patents and technical reports.

How large is the global market for Amoxycillin trihydrate and where is it produced

Recent market analyses estimate the amoxicillin trihydrate market value in the low-to-mid billions USD (various 2024 estimates range roughly around USD 1.2–1.3 billion, with multi-year growth forecasts to 2030+), and market-volume reports indicate tens of thousands of tonnes of product annually; published forecasts project modest CAGRs through the 2020s as generic demand and access to antibiotics continue. Production of active pharmaceutical ingredients (APIs) and finished-dose amoxicillin is concentrated in Asia: China is a dominant supplier of antibiotic APIs while India is a major producer of finished generic antibiotics, with Europe and other regions increasingly dependent on these Asian supply chains. Recent industry coverage and regulatory analyses have highlighted supply-chain concentration risks and shifts of some legacy European production to Asia.