Enalapril maleate price December 2025 and outlook (see chart below)
- India:US$189.18/KG, -0.1% down
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Enalapril maleate price index
This post is a summary of the Enalapril maleate price developments. The price developments of Enalapril maleate are expressed in US$ prices converted FX rates applicable at the time when the price was valid. Enalapril maleate price index developments are calculated from multiple separate sources of data to ensure statistical accuracy.
The outlook for Enalapril maleate prices is generated from different inputs including:
- Very recent price developments of immediate cost drivers of Enalapril maleate prices
- Recent price developments of underlying feedstocks which drive the price of Enalapril maleate
- Market futures for both cost drives and feedstocks of Enalapril maleate prices
- Adjustment of current supply/demand imbalances in the Enalapril maleate market
- Longer term trends in likely demand conditions
What is Enalapril maleate and what is it used for
Enalapril maleate is the maleate‐salt form of the active substance enalapril, an angiotensin-converting-enzyme (ACE) inhibitor. It acts as a pro-drug: after oral administration it is converted into its active metabolite enalaprilat which inhibits ACE, thus reducing the formation of angiotensin II, leading to vasodilation and reduction of blood pressure.
The main therapeutic uses are treatment of hypertension (high blood pressure), symptomatic heart failure, and prevention of symptomatic heart failure in patients with left‐ventricular dysfunction.
How is Enalapril maleate produced
The synthesis of enalapril maleate involves multi‐step chemical reactions. One described route begins with the condensation of the benzyl ester of L-alanyl-L-proline with the ethyl ester of 3-benzoylacrylic acid, followed by reduction (e.g., hydrogenation with Raney nickel) to yield enalapril, which is then converted into its maleate salt form. The maleate salt (maleic acid combined with enalapril) improves stability and formulation properties.
In downstream manufacturing, formulation stability is an important concern: e.g., hot‐melt granulation techniques have been researched to improve chemical stability of enalapril maleate tablets.
How large is the global market for Enalapril maleate and where is it produced
The global market for enalapril maleate is estimated in the realm of around USD 1.6-1.7 billion in 2024. For example, one report states the market size was valued at USD 1.7 billion in 2024 and is forecast to grow to about USD 2.5 billion by 2035.
The active pharmaceutical ingredient (API) and finished dosage forms are produced globally, with major manufacturing centres in China (both API and formulations) and India, as well as production in the USA and Europe.
Specifically, Chinese suppliers dominate export of the API: one data source lists ~98 suppliers in China for enalapril maleate (HSN 2933) exporting globally, with three Chinese companies accounting for ~86% of China’s exports.
Major global manufacturers named include Chinese firms such as Zhejiang Yixin Pharmaceutical Co., Ltd., CSPC Ouyi Pharmaceutical Co., Ltd., Jiangsu Kangyuan Pharmaceutical Co., Ltd., among others.