Glibenclamide price December 2025 and outlook (see chart below)
- India:US$33.93/KG, 0.7% up
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Glibenclamide price index
This post is a summary of the Glibenclamide price developments. The price developments of Glibenclamide are expressed in US$ prices converted FX rates applicable at the time when the price was valid. Glibenclamide price index developments are calculated from multiple separate sources of data to ensure statistical accuracy.
The outlook for Glibenclamide prices is generated from different inputs including:
- Very recent price developments of immediate cost drivers of Glibenclamide prices
- Recent price developments of underlying feedstocks which drive the price of Glibenclamide
- Market futures for both cost drives and feedstocks of Glibenclamide prices
- Adjustment of current supply/demand imbalances in the Glibenclamide market
- Longer term trends in likely demand conditions
What is Glibenclamide and What is It Used For
Glibenclamide (also known as glyburide) is a second‑generation sulfonylurea oral antidiabetic medication. It works by binding to ATP‑sensitive potassium channels (KATP) on pancreatic beta cells, causing depolarization, calcium influx and thereby stimulating the release of insulin. It is used in the treatment of type 2 diabetes mellitus when diet and exercise alone are insufficient to control blood glucose. It is available as a generic medicine and has been approved for use in many countries.
How is Glibenclamide Produced
The chemical synthesis of glibenclamide starts from substituted benzoic acid derivatives (for example 2‑methoxy‑5‑chlorobenzoic acid chloride), which is converted into an amide with 2‑phenylethylamine, then sulfonylation (e.g., chlorosulfonic acid) to form a sulfonamide intermediate, and then reaction with cyclohexylisocyanate to yield glibenclamide. Recent work has shown continuous‐flow methods can achieve higher yields (80‑85 %) for the semi‑telescoped steps within minutes. Commercial production of the active pharmaceutical ingredient (API) is typically carried out in GMP‑certified facilities, and suppliers of glibenclamide API can be found in India, China, Italy, France and elsewhere.
How Large is the Global Market for Glibenclamide and Where Is It Produced
According to one market report for the glibenclamide API segment, the global market size in 2024 was estimated at around USD 285.6 million, and projected to reach about USD 421.8 million by 2033 (with a CAGR of about 4.5 %). Meanwhile another report for glibenclamide tablets estimated the global market size in 2021 at about USD 17.6 billion, to reach around USD 23.3 billion by 2025. The Asia‑Pacific region leads in API manufacturing, with China reportedly accounting for over 60% of global API capacity in that segment. Major production countries include India (for API and finished dosage forms) and China (API manufacturing and intermediates) and European suppliers (for higher‑regulation markets).